Chemical Prophylaxis of Deep Venous Thrombosis in Patients with Severe Traumatic Brain Injury
Deep venous thrombosis (DVT), often prodromal for pulmonary embolism (PE), is known to cause significant morbidity and mortality. There are numerous risk factors for DVT in general, but in neurosurgical patients, risk factors include longer surgery duration, postoperative immobility or paralysis, craniotomy, cancer, and older age. Neurosurgical patients are also at an increased risk of adverse outcomes since the diagnosis of DVT is often delayed or missed if they have altered mental status or altered consciousness. The initiation of chemical prophylaxis is often delayed in neurosurgical patients due to risk of intra cranial hemorrhage.
We hypothesized to see if there is an association between suboptimal chemical prophylactic anticoagulation and development of deep venous thrombosis in patients with severe traumatic brain injury. We are aiming to assess the association between suboptimal chemical prophylactic anticoagulation and development of deep venous thrombosis. Also we will evaluate the association of ICH progression in patients who did and did not receive chemical prophylactic anticoagulation.
The evaluation is being conducted under the guidance of Dr. Ali Seifi, MD, FACP by: